Tuesday 14 June 2011

Cholesterol Synthesis

Statins HMG-CoA reductase inhibitors

Statins

  • Facts:



    Lower cholesterol by inhibiting the enzyme HMG-CoA reductase (rate-limiting enzyme of the mevalonate pathway of cholesterol synthesis)

    Inhibition of this enzyme in the liver results in decreased cholesterol synthesis and increased synthesis of LDL receptors, resulting in an increased clearance of LDL

  • Side Effects:



    Myalgias, muscle cramps
    Rhabdomyolysis

  • Notes:



    Mevalonate is also used for the production of dolichol and CoQ10
    Reduced CoQ10 is implicated in the pathogenesis of statin-induced myopathy

No comments:

Post a Comment